Implementation of Basal-Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen.

ABSTRACT: Background: Barriers to mealtime insulin include complexity, fear of injections, and lifestyle interference. This multicenter, randomized controlled trial evaluated efficacy, safety, and self-reported outcomes in adults with type 2 diabetes, inadequately controlled on basal insulin, initiating and managing mealtime insulin with a wearable patch versus an insulin pen. Methods: Adults with type 2 diabetes (n?=?278, age: 59.2?±?8.9 years), were randomized to patch (n?=?139) versus pen (n?=?139) for 48 weeks, with crossover at week 44. Baseline insulin was divided 1:1 basal: bolus. Using a pattern-control logbook, subjects adjusted basal and bolus insulin weekly using fasting and premeal glucose targets. Results: Glycated hemoglobin (HbA1c) change (least squares mean?±?standard error) from baseline to week 24 (primary endpoint) improved (P?

SUBMITTER: Bergenstal RM 

PROVIDER: S-EPMC6532545 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature