Ontology highlight
ABSTRACT:
SUBMITTER: Fountain E
PROVIDER: S-EPMC6406862 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Fountain Eric E Bassett Roland L RL Cain Suzanne S Posada Liberty L Gombos Dan S DS Hwu Patrick P Bedikian Agop A Patel Sapna P SP
Cancers 20190129 2
Uveal melanoma is a common intraocular malignant tumor that is uniformly fatal once metastatic. No effective adjuvant therapy currently exists to reduce the risk of distant metastasis after definitive treatment of the primary lesion. Immunotherapy has been used effectively in the adjuvant setting in locally advanced cutaneous melanoma. We performed a Phase I/II clinical trial of adjuvant ipilimumab in high-risk primary uveal melanoma with distant metastasis-free survival (DMFS) as the primary ob ...[more]