Phosphorylation-Dependent Regulation of Mammalian Aquaporins.

ABSTRACT: Water homeostasis is fundamental for cell survival. Transport of water across cellular membranes is governed by aquaporins-tetrameric integral membrane channels that are highly conserved throughout the prokaryotic and eukaryotic kingdoms. In eukaryotes, specific regulation of these channels is required and is most commonly carried out by shuttling the protein between cellular compartments (trafficking) or by opening and closing the channel (gating). Structural and functional studies have revealed phosphorylation as a ubiquitous mechanism in aquaporin regulation by both regulatory processes. In this review we summarize what is currently known about the phosphorylation-dependent regulation of mammalian aquaporins. Focusing on the water-specific aquaporins (AQP0⁻AQP5), we discuss how gating a

SUBMITTER: Nesverova V 

PROVIDER: S-EPMC6406877 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature