Ontology highlight
ABSTRACT:
SUBMITTER: Tajer P
PROVIDER: S-EPMC6407064 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Tajer Parisa P Pike-Overzet Karin K Arias Sagrario S Havenga Menzo M Staal Frank J T FJT
Cells 20190218 2
Expansion of hematopoietic stem cells (HSCs) for therapeutic purposes has been a "holy grail" in the field for many years. Ex vivo expansion of HSCs can help to overcome material shortage for transplantation purposes and genetic modification protocols. In this review, we summarize improved understanding in blood development, the effect of niche and conservative signaling pathways on HSCs in mice and humans, and also advances in ex vivo culturing protocols of human HSCs with cytokines or small mo ...[more]