Ontology highlight
ABSTRACT:
SUBMITTER: Mancio-Silva L
PROVIDER: S-EPMC6408324 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Mancio-Silva Liliana L Fleming Heather E HE Miller Alex B AB Milstein Stuart S Liebow Abigail A Haslett Patrick P Sepp-Lorenzino Laura L Bhatia Sangeeta N SN
Cell metabolism 20190301 3
The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In the emerging areas of RNA interference, viral gene therapy, and genome editing, more robust, long-lasting, and predictive human liver models may accelerate progress. Here, we apply a new modality to a previously establ ...[more]