Ontology highlight
ABSTRACT:
SUBMITTER: Leopold AV
PROVIDER: S-EPMC6408446 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Leopold Anna V AV Chernov Konstantin G KG Shemetov Anton A AA Verkhusha Vladislav V VV
Nature communications 20190308 1
Optical control over the activity of receptor tyrosine kinases (RTKs) provides an efficient way to reversibly and non-invasively map their functions. We combined catalytic domains of Trk (tropomyosin receptor kinase) family of RTKs, naturally activated by neurotrophins, with photosensory core module of DrBphP bacterial phytochrome to develop opto-kinases, termed Dr-TrkA and Dr-TrkB, reversibly switchable on and off with near-infrared and far-red light. We validated Dr-Trk ability to reversibly l ...[more]