Ontology highlight
ABSTRACT:
SUBMITTER: Boltz TA
PROVIDER: S-EPMC6408499 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Boltz T A TA Devkota P P Wuchty Stefan S
Scientific reports 20190308 1
Recent research increasingly shows the relevance of network based approaches for our understanding of biological systems. Analyzing human protein interaction networks, we determined collective influencers (CI), defined as network nodes that damage the integrity of the underlying networks to the utmost degree. We found that CI proteins were enriched with essential, regulatory, signaling and disease genes as well as drug targets, indicating their biological significance. Also by focusing on differ ...[more]