Ontology highlight
ABSTRACT:
SUBMITTER: Zhong M
PROVIDER: S-EPMC6609442 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Current opinion in chemical biology 20190323
Protein-protein interactions (PPIs) occur in complex networks. These networks are highly dependent on cellular context and can be extensively altered in disease states such as cancer and viral infection. In recent years, there has been significant progress in developing inhibitors that target individual PPIs either orthosterically (at the interface) or allosterically. These molecules can now be used as tools to dissect PPI networks. Here, we review recent examples that highlight the use of small ...[more]