Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep.
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ABSTRACT:
SUBMITTER: Tianli L
PROVIDER: S-EPMC6409221 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep.
Tianli Liu L Xifeng Wang W Zhenzhong Tian T Lixia Wang W Xingxing Zhang Z Jun Qiao Q Qingling Meng M Shasha Gong G Ying Chen C Xuepeng Cai C
The Korean journal of parasitology 20190226 1
Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) ...[more]
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