Ontology highlight
ABSTRACT:
SUBMITTER: Sato R
PROVIDER: S-EPMC6409751 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sato Ryoichi R Adegawa Satomi S Li Xiaoyi X Tanaka Shiho S Endo Haruka H
Toxins 20190219 2
When ABC transporter family C2 (ABCC2) and ABC transporter family B1 (ABCB1) were heterologously expressed in non-susceptible cultured cells, the cells swelled in response to Cry1A and Cry3 toxins, respectively. Consistent with the notion that 3D-Cry toxins form cation-permeable pores, <i>Bombyx mori</i> ABCC2 (BmABCC2) facilitated cation-permeable pore formation by Cry1A when expressed in <i>Xenopus</i> oocytes. Furthermore, BmABCC2 had a high binding affinity (<i>K<sub>D</sub></i>) to Cry1Aa o ...[more]