Gold Nanocage-Incorporated Poly(?-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy.

ABSTRACT: This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(?-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on?off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.

SUBMITTER: Park JH 

PROVIDER: S-EPMC6410212 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature