Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki T
PROVIDER: S-EPMC6410358 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sasaki Tomoaki T Kudalkar Shalley N SN Bertoletti Nicole N Anderson Karen S KS
Analytical chemistry 20180928 20
Enzymes that catalyze DNA modifying activities including cytidine deamination and cytosine methylation play important biological roles and have been implicated pathologically in diseases such as cancer. Here, we report Direct Resolution of ONE dalton difference (DRONE), an ultra high performance liquid chromatography (UHPLC)-based analytical method to track a single dalton change in the cytosine-to-uracil conversion catalyzed by the human apolipoprotein B m-RNA editing catalytic polypeptide-like ...[more]