Ontology highlight
ABSTRACT:
SUBMITTER: Tsang B
PROVIDER: S-EPMC6410804 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Tsang Brian B Arsenault Jason J Vernon Robert M RM Lin Hong H Sonenberg Nahum N Wang Lu-Yang LY Bah Alaji A Forman-Kay Julie D JD
Proceedings of the National Academy of Sciences of the United States of America 20190214 10
Activity-dependent translation requires the transport of mRNAs within membraneless protein assemblies known as neuronal granules from the cell body toward synaptic regions. Translation of mRNA is inhibited in these granules during transport but quickly activated in response to neuronal stimuli at the synapse. This raises an important question: how does synaptic activity trigger translation of once-silenced mRNAs? Here, we demonstrate a strong connection between phase separation, the process unde ...[more]