Ontology highlight
ABSTRACT:
SUBMITTER: Ozawa T
PROVIDER: S-EPMC6411037 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell reports 20180601 13
The majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA (RELA<sup>FUS</sup>). Neural stem cells transduced with RELA<sup>FUS</sup>ex vivo form ependymomas when implanted in the brain. These tumors display enhanced NF-κB signaling, suggesting that this aberrant signal is the principal mechanism of oncogenesis. However, it is not known whether RELA<sup>FUS</sup> is suffi ...[more]