Ontology highlight
ABSTRACT:
SUBMITTER: Griessner J
PROVIDER: S-EPMC6411154 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Griessner Johannes J Pasieka Manuel M Böhm Vincent V Grössl Florian F Kaczanowska Joanna J Pliota Pinelopi P Kargl Dominic D Werner Barbara B Kaouane Nadia N Strobelt Sandra S Kreitz Silke S Hess Andreas A Haubensak Wulf W
Molecular psychiatry 20181130 2
Benzodiazepines (BZDs) have been a standard treatment for anxiety disorders for decades, but the neuronal circuit interactions mediating their anxiolytic effect remain largely unknown. Here, we find that systemic BZDs modulate central amygdala (CEA) microcircuit activity to gate amygdala output. Combining connectome data with immediate early gene (IEG) activation maps, we identified the CEA as a primary site for diazepam (DZP) anxiolytic action. Deep brain calcium imaging revealed that brain-wid ...[more]