Ontology highlight
ABSTRACT:
SUBMITTER: Kosse C
PROVIDER: S-EPMC6555780 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kosse Christin C Burdakov Denis D
Nature communications 20190607 1
Brain signals that govern memory formation remain incompletely identified. The hypothalamus is implicated in memory disorders, but how its rapidly changing activity shapes memorization is unknown. During encounters with objects, hypothalamic melanin-concentrating hormone (MCH) neurons emit brief signals that reflect object novelty. Here we show that targeted optogenetic silencing of these signals, performed selectively during the initial object encounters (i.e. memory acquisition), prevents futu ...[more]