Ontology highlight
ABSTRACT:
SUBMITTER: Le Q
PROVIDER: S-EPMC6411215 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
PLoS genetics 20190227 2
Activation-induced deaminase (AID) converts C to U and 5-methyl-C to T. These mutagenic activities are critical to immunoglobulin (Ig) gene diversification and epigenetic reprogramming, but they must be tightly controlled to prevent compromising cell fitness. AID acts in the nucleus but localizes predominately to the cytoplasm. To address this apparent paradox, we have carried out time-lapse imaging of AID in single living B cells and fibroblasts. We demonstrate that AID enters the nucleus in br ...[more]