Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine.
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ABSTRACT:
SUBMITTER: Tekola-Ayele F
PROVIDER: S-EPMC6411883 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine.
Tekola-Ayele Fasil F Lee Anthony A Workalemahu Tsegaselassie T Zhang Wei W Shrestha Deepika D Amare Azmeraw T AT Ouidir Marion M
Scientific reports 20190311 1
Before implementing therapeutic genomic interventions for optimizing health in early life, comprehensive understanding of their effect on several traits across the life course is warranted. Abnorml birthweight is associated with cardiometabolic disease risk in adulthood; however, the extent of genetic pleiotropy in the association has not been comprehensively investigated. We tested for pleiotropy and enrichment of functional loci between birthweight and 15 cardiometabolic disease traits (CMD). ...[more]
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