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Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases.


ABSTRACT: BACKGROUND:Obesity during childhood can lead to increased risk of adverse cardiometabolic diseases such as type 2 diabetes and coronary artery disease during adult life. Evidence for strong genetic correlations between child and adult body mass index (BMI) suggest the possibility of shared genetic effects. We performed a test for pleiotropy (shared genetics) and functional enrichment of single nucleotide polymorphisms (SNPs) associated with childhood BMI and 15 adult cardiometabolic traits using a unified statistical approach that integrates pleiotropy and functional annotation data. RESULTS:Pleiotropic genetic effects were significantly abundant in 13 out of 15 childhood BMI-adult cardiometabolic trait tests (P?

SUBMITTER: Tekola-Ayele F 

PROVIDER: S-EPMC6449964 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases.

Tekola-Ayele Fasil F   Lee Anthony A   Workalemahu Tsegaselassie T   Sánchez-Pozos Katy K  

Human genomics 20190404 1


<h4>Background</h4>Obesity during childhood can lead to increased risk of adverse cardiometabolic diseases such as type 2 diabetes and coronary artery disease during adult life. Evidence for strong genetic correlations between child and adult body mass index (BMI) suggest the possibility of shared genetic effects. We performed a test for pleiotropy (shared genetics) and functional enrichment of single nucleotide polymorphisms (SNPs) associated with childhood BMI and 15 adult cardiometabolic trai  ...[more]

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