Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases.
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ABSTRACT:
SUBMITTER: Tekola-Ayele F
PROVIDER: S-EPMC6449964 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases.
Tekola-Ayele Fasil F Lee Anthony A Workalemahu Tsegaselassie T Sánchez-Pozos Katy K
Human genomics 20190404 1
<h4>Background</h4>Obesity during childhood can lead to increased risk of adverse cardiometabolic diseases such as type 2 diabetes and coronary artery disease during adult life. Evidence for strong genetic correlations between child and adult body mass index (BMI) suggest the possibility of shared genetic effects. We performed a test for pleiotropy (shared genetics) and functional enrichment of single nucleotide polymorphisms (SNPs) associated with childhood BMI and 15 adult cardiometabolic trai ...[more]
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