Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC6411943 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhang Shaoyi S Wang Yan Y Xie Wei W Howe Ethan N W ENW Busschaert Nathalie N Sauvat Allan A Leduc Marion M Gomes-da-Silva Lígia C LC Chen Guo G Martins Isabelle I Deng Xiaxing X Maiuri Luigi L Kepp Oliver O Soussi Thierry T Gale Philip A PA Zamzami Naoufal N Kroemer Guido G
Cell death & disease 20190311 3
Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate insufficient chloride fluxes. Here, we report that such chloride anionophores block autophagic flux in spite of the fact that they activate the pro-autophagic transcription factor EB (TFEB) coupled to the inhibition of the autophagy-suppressive mTORC1 kinase activity. Two synth ...[more]