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Behavioral, electrophysiological and neuropathological characteristics of the occurrence of hypertension in pregnant rats.

ABSTRACT: Pre-eclampsia (PE) affects approximately 2 to 8% of pregnant women, causing blood pressure above 140?×?90?mmHg and proteinuria, normally after the 20th gestation week. If unsuccessfully treated, PE can lead to self-limited seizures (Eclampsia) that could eventually result in death of the mother and her fetus. The present study reports an experimental model of preeclampsia hypertension in pregnant (HP) and non-pregnant (H) Wistar rats by partially clamping one of their renal arteries. Pregnant (P) and non-pregnant (C) controls were provided. Differently from controls (C and P), H and HP animals presented a steady rise in BP two weeks after renal artery clamping. Injection of pentylenetetrazol (PTZ) induced behavioral and electroencephalographic seizures in all groups, which were increased in number, duration, amplitude and power accompanied by decreased latency in HP animals (p?

SUBMITTER: Oliveira LF 

PROVIDER: S-EPMC6412065 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Behavioral, electrophysiological and neuropathological characteristics of the occurrence of hypertension in pregnant rats.

Oliveira Leandro F LF   Pinheiro Daniel J L L DJLL   Rodrigues Laís D LD   Reyes-Garcia Selvin Z SZ   Nishi Erika E EE   Ormanji Milene S MS   Faber Jean J   Cavalheiro Esper A EA  

Scientific reports 20190311 1

Pre-eclampsia (PE) affects approximately 2 to 8% of pregnant women, causing blood pressure above 140 × 90 mmHg and proteinuria, normally after the 20th gestation week. If unsuccessfully treated, PE can lead to self-limited seizures (Eclampsia) that could eventually result in death of the mother and her fetus. The present study reports an experimental model of preeclampsia hypertension in pregnant (HP) and non-pregnant (H) Wistar rats by partially clamping one of their renal arteries. Pregnant (P  ...[more]

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