Dataset Information

Neuropathological and transcriptomic characteristics of the aged brain.

ABSTRACT: As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging.brain-map.org/). We confirm established associations between AD pathology and dementia, albeit with increased, presumably aging-related variability, and identify sets of co-expressed genes correlated with pathological tau and inflammation markers. Finally, we demonstrate a relationship between dementia and RNA quality, and find common gene signatures, highlighting the importance of properly controlling for RNA quality when studying dementia.

SUBMITTER: Miller JA

PROVIDER: S-EPMC5679757 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Neuropathological and transcriptomic characteristics of the aged brain.

Miller Jeremy A JA Guillozet-Bongaarts Angela A Gibbons Laura E LE Postupna Nadia N Renz Anne A Beller Allison E AE Sunkin Susan M SM Ng Lydia L Rose Shannon E SE Smith Kimberly A KA Szafer Aaron A Barber Chris C Bertagnolli Darren D Bickley Kristopher K Brouner Krissy K Caldejon Shiella S Chapin Mike M Chua Mindy L ML Coleman Natalie M NM Cudaback Eiron E Cuhaciyan Christine C Dalley Rachel A RA Dee Nick N Desta Tsega T Dolbeare Tim A TA Dotson Nadezhda I NI Fisher Michael M Gaudreault Nathalie N Gee Garrett G Gilbert Terri L TL Goldy Jeff J Griffin Fiona F Habel Caroline C Haradon Zeb Z Hejazinia Nika N Hellstern Leanne L LL Horvath Steve S Howard Kim K Howard Robert R Johal Justin J Jorstad Nikolas L NL Josephsen Samuel R SR Kuan Chihchau L CL Lai Florence F Lee Eric E Lee Felix F Lemon Tracy T Li Xianwu X Marshall Desiree A DA Melchor Jose J Mukherjee Shubhabrata S Nyhus Julie J Pendergraft Julie J Potekhina Lydia L Rha Elizabeth Y EY Rice Samantha S Rosen David D Sapru Abharika A Schantz Aimee A Shen Elaine E Sherfield Emily E Shi Shu S Sodt Andy J AJ Thatra Nivretta N Tieu Michael M Wilson Angela M AM Montine Thomas J TJ Larson Eric B EB Bernard Amy A Crane Paul K PK Ellenbogen Richard G RG Keene C Dirk CD Lein Ed E

eLife 20171109

As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, ...[more]

PMID: 29120328

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Dataset Information

Neuropathological and transcriptomic characteristics of the aged brain.

Publications

Neuropathological and transcriptomic characteristics of the aged brain.

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