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A Comprehensive Study on the Dye Adsorption Behavior of Polyoxometalate-Complex Nano-Hybrids Containing Classic ?-Octamolybdate and Biimidazole Units.

ABSTRACT: Six new hybrids based on ?-[Mo?O26]4- polyoxometalates, [Ni(H?biim)?]?[?-Mo?O26]•8DMF(1); (DMA)?[M(H?biim)?(H?O)?][?-Mo?O26]•4DMF (M = Ni (2), Co (3)), DMA = dimethyl-ammonium, H?biim=2,2'-biimidazole); [M(H?biim)(DMF)?]?[?-Mo?O26]•2DMF (M = Zn (4), Cu (5)); [(DMA)?[Cu(DMF)?][?-Mo?O26]•2DMF]n (6), have been successfully synthesized and characterized. Compounds 2?5 show favorable capacity to adsorb methylene blue (MB) at room temperature, and they can selectively capture MB molecules from binary-mixture solutions of MB/MO (MO = Methyl Orange), or MB/RhB (RhB = Rhodamine B). Compound 3 can uptake up to 521.7 mg g-1 MB cationic dyes rapidly, which perform the maximum adsorption in an hour among the reported materials as far as we know. The compounds are stable and still work very efficiently after three cycles. For compound 3, the preliminary adsorption mechanism studies indicated that the adsorption is an ion exchange process and the adsorption behavior of polyoxometalate-complex can be benefited from additional exchangeable protons in the complex cations.

SUBMITTER: Liang S

PROVIDER: S-EPMC6412703 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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A Comprehensive Study on the Dye Adsorption Behavior of Polyoxometalate-Complex Nano-Hybrids Containing Classic β-Octamolybdate and Biimidazole Units.

Liang Shuang S Nie Yan-Mei YM Li Sang-Hao SH Zhou Jian-Liang JL Yan Jun J

Molecules (Basel, Switzerland) 20190222 4

Six new hybrids based on β-[Mo₈O26]4- polyoxometalates, [Ni(H₂biim)₃]₂[β-Mo₈O26]•8DMF(1); (DMA)₂[M(H₂biim)₂(H₂O)₂][β-Mo₈O26]•4DMF (M = Ni (2), Co (3)), DMA = dimethyl-ammonium, H₂biim=2,2'-biimidazole); [M(H₂biim)(DMF)₃]₂[β-Mo₈O26]•2DMF (M = Zn (4), Cu (5)); [(DMA)₂[Cu(DMF)₄][β-Mo₈O26]•2DMF]n (6), have been successfully synthesized and characterized. Compounds 2⁻5 show fa ...[more]

PMID: 30813387

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Project description:BACKGROUND:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor drugs. RESULTS:The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse polyoxometalates. Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class. Further, organically modified Dawson polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity. The size of the polyoxometalates and its derivitization were found to be the key determinants of their potency. CONCLUSION:Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.

Dataset Information

A Comprehensive Study on the Dye Adsorption Behavior of Polyoxometalate-Complex Nano-Hybrids Containing Classic ?-Octamolybdate and Biimidazole Units.

Publications

A Comprehensive Study on the Dye Adsorption Behavior of Polyoxometalate-Complex Nano-Hybrids Containing Classic β-Octamolybdate and Biimidazole Units.

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