Neurocognitive and neuroanatomical maturation in the clinical high-risk states for psychosis: A pattern recognition study.

ABSTRACT: BACKGROUND:Findings from neurodevelopmental studies indicate that adolescents with psychosis spectrum disorders have delayed neurocognitive performance relative to the maturational state of their healthy peers. Using machine learning, we generated a model of neurocognitive age in healthy adults and investigated whether individuals in clinical high risk (CHR) for psychosis showed systematic neurocognitive age deviations that were accompanied by specific structural brain alterations. METHODS:First, a Support Vector Regression-based age prediction model was trained and cross-validated on the neurocognitive data of 36 healthy controls (HC). This produced Cognitive Age Gap Estimates (CogAGE) that measured each participant's deviation from the normal cognitive maturation as the difference between estimated neurocognitive and chronological age. Second, we employed voxel-based morphometry to explore the neuroanatomical gray and white matter correlates of CogAGE in HC, in CHR individuals with early (CHR-E) and late (CHR-L) high risk states. RESULTS:The age prediction model estimated age in HC subjects with a mean absolute error of ±2.2?years (SD?=?3.3; R2?=?0.33, P?

SUBMITTER: Kambeitz-Ilankovic L 

PROVIDER: S-EPMC6413470 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature