Ontology highlight
ABSTRACT:
SUBMITTER: Stone S
PROVIDER: S-EPMC6413796 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Stone Sarrabeth S Yue Yuan Y Stanojlovic Milos M Wu Shuangchan S Karsenty Gerard G Lin Wensheng W
JCI insight 20190124 2
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating and neurodegenerative diseases of the CNS. Although neurodegeneration is the major contributor to chronic disability in MS, mechanisms governing the viability of axons and neurons in MS and EAE remain elusive. Data indicate that activation of pancreatic endoplasmic reticulum kinase (PERK) influences, positively or negatively, neuron and axon viability in various n ...[more]