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An anatomic transcriptional atlas of human glioblastoma.

ABSTRACT: Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

SUBMITTER: Puchalski RB 

PROVIDER: S-EPMC6414061 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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An anatomic transcriptional atlas of human glioblastoma.

Puchalski Ralph B RB   Shah Nameeta N   Miller Jeremy J   Dalley Rachel R   Nomura Steve R SR   Yoon Jae-Guen JG   Smith Kimberly A KA   Lankerovich Michael M   Bertagnolli Darren D   Bickley Kris K   Boe Andrew F AF   Brouner Krissy K   Butler Stephanie S   Caldejon Shiella S   Chapin Mike M   Datta Suvro S   Dee Nick N   Desta Tsega T   Dolbeare Tim T   Dotson Nadezhda N   Ebbert Amanda A   Feng David D   Feng Xu X   Fisher Michael M   Gee Garrett G   Goldy Jeff J   Gourley Lindsey L   Gregor Benjamin W BW   Gu Guangyu G   Hejazinia Nika N   Hohmann John J   Hothi Parvinder P   Howard Robert R   Joines Kevin K   Kriedberg Ali A   Kuan Leonard L   Lau Chris C   Lee Felix F   Lee Hwahyung H   Lemon Tracy T   Long Fuhui F   Mastan Naveed N   Mott Erika E   Murthy Chantal C   Ngo Kiet K   Olson Eric E   Reding Melissa M   Riley Zack Z   Rosen David D   Sandman David D   Shapovalova Nadiya N   Slaughterbeck Clifford R CR   Sodt Andrew A   Stockdale Graham G   Szafer Aaron A   Wakeman Wayne W   Wohnoutka Paul E PE   White Steven J SJ   Marsh Don D   Rostomily Robert C RC   Ng Lydia L   Dang Chinh C   Jones Allan A   Keogh Bart B   Gittleman Haley R HR   Barnholtz-Sloan Jill S JS   Cimino Patrick J PJ   Uppin Megha S MS   Keene C Dirk CD   Farrokhi Farrokh R FR   Lathia Justin D JD   Berens Michael E ME   Iavarone Antonio A   Bernard Amy A   Lein Ed E   Phillips John W JW   Rostad Steven W SW   Cobbs Charles C   Hawrylycz Michael J MJ   Foltz Greg D GD  

Science (New York, N.Y.) 20180501 6389

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallm  ...[more]

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