Ontology highlight
ABSTRACT:
SUBMITTER: Nandagopal N
PROVIDER: S-EPMC6414217 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nandagopal Nagarajan N Santat Leah A LA LeBon Lauren L Sprinzak David D Bronner Marianne E ME Elowitz Michael B MB
Cell 20180201 4
The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination could occur. Here, we show that cells use dynamics to discriminate signaling by the ligands Dll1 and Dll4 through the Notch1 receptor. Quantitative single-cell imaging revealed that Dll1 activates Notch1 in discrete, frequency-modulated pulses that s ...[more]