Ontology highlight
ABSTRACT:
SUBMITTER: Mitra A
PROVIDER: S-EPMC7221189 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Mitra Ankita A Shanthalingam Sudarvili S Sherman Heather L HL Singh Khushboo K Canakci Mine M Torres Joe A JA Lawlor Rebecca R Ran Yong Y Golde Todd E TE Miele Lucio L Thayumanavan Sankaran S Minter Lisa M LM Osborne Barbara A BA
Frontiers in immunology 20200507
Notch signaling provides an important cue in the mammalian developmental process. It is a key player in T cell development and function. Notch ligands such as Delta-like ligands (DLL) 1, 3, 4, and JAG1, 2 can impact Notch signaling positively or negatively, by <i>trans</i>-activation or <i>cis</i>-inhibition. <i>Trans</i> and <i>cis</i> interactions are receptor-ligand interaction on two adjacent cells and interaction on the same cell, respectively. The former sends an activation signal and the ...[more]