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Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross-Coupling.

ABSTRACT: Catalytic enantioselective conjunctive cross-coupling has been developed to construct tertiary alkylboronic esters. These reactions occur with good yield and enantioselectivity for a range of substrates. Mechanistic experiments reveal aspects of the catalytic cycle that allow hindered substrates to react without significant complicating side reactions.

SUBMITTER: Myhill JA

PROVIDER: S-EPMC6414220 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross-Coupling.

Myhill Jesse A JA Zhang Liang L Lovinger Gabriel J GJ Morken James P JP

Angewandte Chemie (International ed. in English) 20180829 39

Catalytic enantioselective conjunctive cross-coupling has been developed to construct tertiary alkylboronic esters. These reactions occur with good yield and enantioselectivity for a range of substrates. Mechanistic experiments reveal aspects of the catalytic cycle that allow hindered substrates to react without significant complicating side reactions. ...[more]

PMID: 30091829

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