Ontology highlight
ABSTRACT:
SUBMITTER: Deng JH
PROVIDER: S-EPMC6414311 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Pathogens and disease 20190201 1
Macrophages are the primary host target cells of Mycobacterium tuberculosis (M. tb). As a subunit of immunoregulatory cytokines IL-27 and IL-35, Epstein-Barr virus-induced gene 3 (EBI3) has typically been explored as the secreted form and assessed in terms of its effects triggered by extracellular EBI3. However, little is known about intracellular EBI3 function. In the current study, we report that EBI3 production by macrophages is elevated in TB patients. We further demonstrate that increased E ...[more]