CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
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ABSTRACT:
SUBMITTER: Vassal-Stermann E
PROVIDER: S-EPMC6414520 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
Vassal-Stermann Emilie E Effantin Gregory G Zubieta Chloe C Burmeister Wim W Iseni Frédéric F Wang Hongjie H Lieber André A Schoehn Guy G Fender Pascal P
Nature communications 20190312 1
Attachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a cellular receptor. Here we report the cryo-electron microscopy (cryo-EM) structure of a <100 kDa non-symmetrical complex comprising the trimeric HAd type 3 fibre knob (HAd3K) and human desmoglein 2 (DSG2). The structure reveals a unique stoichiometry of 1:1 and 2:1 (DSG2: knob trimer) not previously observed for other HAd-receptor complexes. ...[more]
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