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ABSTRACT:
SUBMITTER: Vassal-Stermann E
PROVIDER: S-EPMC6891581 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Vassal-Stermann Emilie E Hutin Stephanie S Fender Pascal P Burmeister Wim P WP
Acta crystallographica. Section F, Structural biology communications 20191127 Pt 12
The cryo-electron microscopy (cryo-EM) structure of the complex between the trimeric human adenovirus B serotype 3 fibre knob and human desmoglein 2 fragments containing cadherin domains EC2 and EC3 has been published, showing 3:1 and 3:2 complexes. Here, the crystal structure determined at 4.5 Å resolution is presented with one EC2-EC3 desmoglein fragment bound per fibre knob monomer in the asymmetric unit, leading to an apparent 3:3 stoichiometry. However, in concentrated solution the 3:2 comp ...[more]