Ontology highlight
ABSTRACT:
SUBMITTER: Vaeth M
PROVIDER: S-EPMC6414608 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Vaeth Martin M Wang Yin-Hu YH Eckstein Miriam M Yang Jun J Silverman Gregg J GJ Lacruz Rodrigo S RS Kannan Kasthuri K Feske Stefan S
Nature communications 20190312 1
T regulatory (Treg) cells maintain immunological tolerance and organ homeostasis. Activated Treg cells differentiate into effector Treg subsets that acquire tissue-specific functions. Ca<sup>2+</sup> influx via Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) channels formed by STIM and ORAI proteins is required for the thymic development of Treg cells, but its function in mature Treg cells remains unclear. Here we show that deletion of Stim1 and Stim2 genes in mature Treg cells abolishe ...[more]