Ontology highlight
ABSTRACT:
SUBMITTER: Oishi K
PROVIDER: S-EPMC6414799 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Oishi Kohei K Yamayoshi Seiya S Kawaoka Yoshihiro Y
Frontiers in microbiology 20190306
The influenza virus protein PA-X modulates the host immune responses and viral pathogenicity through suppression of host protein expression. The endonuclease active site in the N-terminal region, the basic amino acid cluster in the C-terminal PA-X-specific region, and N-terminal acetylation of PA-X by NatB are important for the shutoff activity of PA-X. Here, we focused on the shutoff activity of PA-X derived from the A/California/04/2009 and A/WSN/33 viruses because these two PA-X proteins diff ...[more]