Ontology highlight
ABSTRACT:
SUBMITTER: DesRochers BL
PROVIDER: S-EPMC5551402 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
DesRochers Brittany L BL Chen Rita E RE Gounder Anshu P AP Pinto Amelia K AK Bricker Traci T Linton Camille N CN Rogers Corianne D CD Williams Graham D GD Webby Richard J RJ Boon Adrianus C M AC
Virology 20160420
Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are not well understood. We used DBA/2 mice to identify viral factors that mediate the difference in pathogenesis between a virulent (H7N3) and a non-virulent (H7N9) avian influenza virus from North America. In vitro and in vivo characterization of reassortant viruses identified the PB2 and PA polymerase genes as major determinants of H7N3 pathogenesis. ...[more]