Synthesis and Self-Assembly of Double-Hydrophilic and Amphiphilic Block Glycopolymers.

ABSTRACT: In this report, we present double-hydrophilic block glycopolymers of poly(2-hydroxyethyl methacrylate)- b-poly(2-(?-glucosyloxy)ethyl methacrylate) (PHEMA- b-PGEMA) and amphiphilic block glycopolymers of poly(ethyl methacrylate)- b-PGEMA (PEMA- b-PGEMA) synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block glycopolymers were prepared in two compositions of P(H)EMA macro-chain transfer agents (CTAs) and similar molecular weights of PGEMA. Structural analysis of the resulting polymers as well as the conversion of (H)EMA and GEMA monomers were determined by ¹H NMR spectroscopy. Size exclusion chromatography measurements confirmed both P(H)EMA macro-CTAs and block glycopolymers had a low dispersity ( ? ? 1.5). The synthesized block glycopolymers had a degree of polymerization and a molecular weight up to 222 and 45.3 kg mol^-1, respectively. Both block glycopolymers self-assembled into micellar structures in aqueous solutions as characterized by fluorescence spectroscopy, ultraviolet-visible spectroscopy, and dynamic light scattering experiments.

SUBMITTER: Adharis A 

PROVIDER: S-EPMC6415355 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature