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Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers.

ABSTRACT: A new family of alkynylated, amphiphilic dendrimers consisting of amidoamine linkers connected to 5,5'-functionalized 2,2'-bipyridine cores has been developed and evaluated in the formation of metallodendrimers of different generations and in self-assembly protocols. A convergent synthetic strategy was applied to provide dumbbell-shaped amphiphilic dendrimers, where the 2,2'-bipyridine cores could be coordinated to FeII centers to afford corresponding metallodendrimers. The ability of the metallic- and non-metallic dendritic structures to self-assemble into functional supramolecular aggregates were furthermore evaluated in aqueous solution. Spherical aggregates with sizes of a few hundred nanometers were generally produced, where controlled disassembly of the metallodendrimers through decomplexation could be achieved.

SUBMITTER: Neranon K

PROVIDER: S-EPMC6948116 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers.

Neranon Kitjanit K Alberch Laura L Ramström Olof O

ChemistryOpen 20200108 1

A new family of alkynylated, amphiphilic dendrimers consisting of amidoamine linkers connected to 5,5'-functionalized 2,2'-bipyridine cores has been developed and evaluated in the formation of metallodendrimers of different generations and in self-assembly protocols. A convergent synthetic strategy was applied to provide dumbbell-shaped amphiphilic dendrimers, where the 2,2'-bipyridine cores could be coordinated to Fe<sup>II</sup> centers to afford corresponding metallodendrimers. The ability of ...[more]

PMID: 31921545

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Project description:BackgroundThe ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials.ResultsIn the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle's physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells.ConclusionCurcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core.

Dataset Information

Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers.

Publications

Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers.

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