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The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties.

ABSTRACT: Polydimethylsiloxane (PDMS) is a silicone elastomer-based material that is used in various applications, including coatings, tubing, microfluidics, and medical implants. PDMS has been modified with hydrogel coatings to prevent fouling, which can be done through UV-mediated free radical polymerization using benzophenone. However, to the best of our knowledge, the properties of hydrogel coatings and their influence on the bulk properties of PDMS under various preparation conditions, such as the type and concentration of monomers, and UV treatment time, have never been investigated. Acrylate-based monomers were used to perform free radical polymerization on PDMS surfaces under various reaction conditions. This approach provides insights into the relationship between the hydrogel coating and bulk properties of PDMS. Altering the UV polymerization time and the monomer concentration resulted in different morphologies with different roughness and thickness of the hydrogel coating, as well as differences in the bulk material stiffness. The surface morphology of the coated PDMS was characterized by AFM. The cross section and thickness of the coatings were examined using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. The dependence of coating development on the monomer type and concentration used was evaluated by surface hydrophilicity, as measured by water contact angle. Elongation-until-break analysis revealed that specific reaction conditions affected the bulk properties and made the coated PDMS brittle. Therefore, boundary conditions have been identified to enable high quality hydrogel coating formation without affecting the bulk properties of the material.

SUBMITTER: Keskin D

PROVIDER: S-EPMC6415430 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties.

Keskin Damla D Mokabbar Taraneh T Pei Yutao Y Van Rijn Patrick P

Polymers 20180516 5

Polydimethylsiloxane (PDMS) is a silicone elastomer-based material that is used in various applications, including coatings, tubing, microfluidics, and medical implants. PDMS has been modified with hydrogel coatings to prevent fouling, which can be done through UV-mediated free radical polymerization using benzophenone. However, to the best of our knowledge, the properties of hydrogel coatings and their influence on the bulk properties of PDMS under various preparation conditions, such as the ty ...[more]

PMID: 30966568

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Project description:PurposeTo compare the subjective performances of verofilcon A daily disposable silicone hydrogel contact lenses (CLs) and etafilcon A hydrogel CLs.MethodsSuccessful wearers of spherical soft CLs for distance correction were prospectively randomized to wear verofilcon A or etafilcon A lenses for 1 week and crossed over to the alternative lenses. The primary study objective was a comparison of distance visual acuity (VA). Exploratory endpoints included subjective overall lens preference (5-point scale) and subjective ratings (10-point scales) of end-of-day (EOD) vision, overall handling, insertion comfort, EOD comfort, overall quality of vision, overall comfort, vision throughout the day, lens handling at insertion, and lens handling at removal.ResultsOf 92 subjects (184 eyes), 46 each were randomized to verofilcon A or etafilcon A lenses and subsequently crossed over to the other lenses. Evaluation of distance VA showed that verofilcon A lenses were noninferior to etafilcon A lenses. Comparison of lens preference showed that 68 (73.9%) subjects somewhat or strongly preferred verofilcon A lenses, whereas 21 (22.9%) somewhat or strongly preferred etafilcon A lenses (p<0.0001). Mean ± SD ratings of EOD vision (8.6±1.5 vs 7.7±1.9), overall handling (8.7±1.5 vs 6.9±2.3), insertion comfort (9.2±1.0 vs 7.7±1.9), and EOD comfort (8.0±1.9 vs 7.0±2.2) were all significantly (p≤0.0001 each) higher for verofilcon A than for etafilcon A lenses. Mean ± SD ratings of overall quality of vision (8.9±1.2 vs 8.2±1.8), overall comfort (8.6±1.5 vs 7.4±1.8), vision throughout the day (8.9±1.3 vs 8.1±1.8), lens handling at insertion (9.0±1.4 vs 6.9±2.5), and lens handling at removal (8.3±2.1 vs 7.7±2.2) were also significantly higher for verofilcon A lenses. No subject experienced any ocular adverse events.ConclusionAfter 1 week of wear, the study population reported that ratings for subjective endpoints were significantly higher for verofilcon A lenses than for etafilcon A lenses.

Dataset Information

The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties.

Publications

The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties.

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