Ontology highlight
ABSTRACT:
SUBMITTER: Kaelberer MM
PROVIDER: S-EPMC6417812 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kaelberer Melanie Maya MM Buchanan Kelly L KL Klein Marguerita E ME Barth Bradley B BB Montoya Marcia M MM Shen Xiling X Bohórquez Diego V DV
Science (New York, N.Y.) 20180901 6408
The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the putative gut epithelial sensor cell-the enteroendocrine cell. However, these electrically excitable cells contain several features of epithelial transducers. Using a mouse model, we found that enteroendocrine cells synapse with vagal neurons to transduce gut luminal signals in milliseconds by using glutamate as a neurotransmitter. These sy ...[more]