Ontology highlight
ABSTRACT:
SUBMITTER: Greer ER
PROVIDER: S-EPMC2556218 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Greer Elisabeth R ER Pérez Carissa L CL Van Gilst Marc R MR Lee Brian H BH Ashrafi Kaveh K
Cell metabolism 20080801 2
A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological, and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-beta ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple in ...[more]