Ontology highlight
ABSTRACT:
SUBMITTER: Campbell KM
PROVIDER: S-EPMC6417872 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Campbell Katie M KM Lin Tianxiang T Zolkind Paul P Barnell Erica K EK Skidmore Zachary L ZL Winkler Ashley E AE Law Jonathan H JH Mardis Elaine R ER Wartman Lukas D LD Adkins Douglas R DR Chernock Rebecca D RD Griffith Malachi M Uppaluri Ravindra R Griffith Obi L OL
Cell reports 20180801 8
Herein, we report an oral cavity squamous cell carcinoma (OCSCC) patient-derived xenograft (PDX) platform, with genomic annotation useful for co-clinical trial and mechanistic studies. Genomic analysis included whole-exome sequencing (WES) and transcriptome sequencing (RNA-seq) on 16 tumors and matched PDXs and additional whole-genome sequencing (WGS) on 9 of these pairs as a representative subset of a larger OCSCC PDX repository (n = 63). In 12 models with high purity, more than 90% of variants ...[more]