MiR-214 sensitizes human colon cancer cells to 5-FU by targeting Hsp27.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC6419349 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
MiR-214 sensitizes human colon cancer cells to 5-FU by targeting Hsp27.
Yang Yong Y Bao Yan Y Yang Guo-Kai GK Wan Jia J Du Ling-Juan LJ Ma Zhen-Huan ZH
Cellular & molecular biology letters 20190314
Overcoming chemorestistance to 5-fluorouracil (5-FU) could offer a new treatment option for highly malignant colon cancer. In our study, differential microRNA expression profiling revealed that miR-214 is downregulated in 5-FU-resistant colon cancer cells compared to normal cells. In vitro, miR-214 could sensitize non-resistant colon cancer cells and 5-FU-resistant colon cancer cellsto 5-FU. Functionally, miR-214 inhibited cell clone formation and cell growth and enhanced 5-FU-inducing cell apop ...[more]
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