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Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007-2012: the importance of comprehensive data availability.


ABSTRACT: Background:Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approach applied to the same subjects may allow a more useful classification compared to the hypothesis-driven one. Aim:To compare previously defined hypothesis-driven with newly derived data-driven asthma phenotypes, identified by latent class analysis (LCA), in adults with current asthma from NHANES 2007-2012. Methods:Adults (??18 years) with current asthma from the NHANES were included (n?=?1059). LCA included variables commonly used to subdivide asthma. LCA models were derived independently according to age groups: ?0.05). Class A

SUBMITTER: Amaral R 

PROVIDER: S-EPMC6419396 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007-2012: the importance of comprehensive data availability.

Amaral Rita R   Pereira Ana M AM   Jacinto Tiago T   Malinovschi Andrei A   Janson Christer C   Alving Kjell K   Fonseca João A JA  

Clinical and translational allergy 20190313


<h4>Background</h4>Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approach applied to the same subjects may allow a more useful classification compared to the hypothesis-driven one.<h4>Aim</h4>To compare previously defined hypothesis-driven with newly derived data-driven asthma phenotypes, identified by latent class analysis (LCA), in adults  ...[more]

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