Dataset Information

Design, implementation, and operation of a rapid, robust named entity recognition web service.

ABSTRACT: Most BioCreative tasks to date have focused on assessing the quality of text-mining annotations in terms of precision and recall. Interoperability, speed, and stability are, however, other important factors to consider for practical applications of text mining. For about a decade, we have run named entity recognition (NER) web services, which are designed to be efficient, implemented using a multi-threaded queueing system to robustly handle many simultaneous requests, and hosted at a supercomputer facility. To participate in this new task, we extended the existing NER tagging service with support for the BeCalm API. The tagger suffered no downtime during the challenge and, as in earlier tests, proved to be highly efficient, consistently processing requests of 5000 abstracts in less than half a minute. In fact, the majority of this time was spent not on the NER task but rather on retrieving the document texts from the challenge servers. The latter was found to be the main bottleneck even when hosting a copy of the tagging service on a Raspberry Pi 3, showing that local document storage or caching would be desirable features to include in future revisions of the API standard.

SUBMITTER: Pletscher-Frankild S

PROVIDER: S-EPMC6419787 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Design, implementation, and operation of a rapid, robust named entity recognition web service.

Pletscher-Frankild Sune S Jensen Lars Juhl LJ

Journal of cheminformatics 20190308 1

Most BioCreative tasks to date have focused on assessing the quality of text-mining annotations in terms of precision and recall. Interoperability, speed, and stability are, however, other important factors to consider for practical applications of text mining. For about a decade, we have run named entity recognition (NER) web services, which are designed to be efficient, implemented using a multi-threaded queueing system to robustly handle many simultaneous requests, and hosted at a supercomput ...[more]

PMID: 30850898

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Project description:MotivationThe explosive increase of biomedical literature has made information extraction an increasingly important tool for biomedical research. A fundamental task is the recognition of biomedical named entities in text (BNER) such as genes/proteins, diseases and species. Recently, a domain-independent method based on deep learning and statistical word embeddings, called long short-term memory network-conditional random field (LSTM-CRF), has been shown to outperform state-of-the-art entity-specific BNER tools. However, this method is dependent on gold-standard corpora (GSCs) consisting of hand-labeled entities, which tend to be small but highly reliable. An alternative to GSCs are silver-standard corpora (SSCs), which are generated by harmonizing the annotations made by several automatic annotation systems. SSCs typically contain more noise than GSCs but have the advantage of containing many more training examples. Ideally, these corpora could be combined to achieve the benefits of both, which is an opportunity for transfer learning. In this work, we analyze to what extent transfer learning improves upon state-of-the-art results for BNER.ResultsWe demonstrate that transferring a deep neural network (DNN) trained on a large, noisy SSC to a smaller, but more reliable GSC significantly improves upon state-of-the-art results for BNER. Compared to a state-of-the-art baseline evaluated on 23 GSCs covering four different entity classes, transfer learning results in an average reduction in error of approximately 11%. We found transfer learning to be especially beneficial for target datasets with a small number of labels (approximately 6000 or less).Availability and implementationSource code for the LSTM-CRF is available at https://github.com/Franck-Dernoncourt/NeuroNER/ and links to the corpora are available at https://github.com/BaderLab/Transfer-Learning-BNER-Bioinformatics-2018/.Supplementary informationSupplementary data are available at Bioinformatics online.

Project description:MotivationText mining is increasingly used to manage the accelerating pace of the biomedical literature. Many text mining applications depend on accurate named entity recognition (NER) and normalization (grounding). While high performing machine learning methods trainable for many entity types exist for NER, normalization methods are usually specialized to a single entity type. NER and normalization systems are also typically used in a serial pipeline, causing cascading errors and limiting the ability of the NER system to directly exploit the lexical information provided by the normalization.MethodsWe propose the first machine learning model for joint NER and normalization during both training and prediction. The model is trainable for arbitrary entity types and consists of a semi-Markov structured linear classifier, with a rich feature approach for NER and supervised semantic indexing for normalization. We also introduce TaggerOne, a Java implementation of our model as a general toolkit for joint NER and normalization. TaggerOne is not specific to any entity type, requiring only annotated training data and a corresponding lexicon, and has been optimized for high throughput.ResultsWe validated TaggerOne with multiple gold-standard corpora containing both mention- and concept-level annotations. Benchmarking results show that TaggerOne achieves high performance on diseases (NCBI Disease corpus, NER f-score: 0.829, normalization f-score: 0.807) and chemicals (BioCreative 5 CDR corpus, NER f-score: 0.914, normalization f-score 0.895). These results compare favorably to the previous state of the art, notwithstanding the greater flexibility of the model. We conclude that jointly modeling NER and normalization greatly improves performance.Availability and implementationThe TaggerOne source code and an online demonstration are available at: http://www.ncbi.nlm.nih.gov/bionlp/taggeroneContactzhiyong.lu@nih.govSupplementary informationSupplementary data are available at Bioinformatics online.

Project description:Increased interest in the use of word embeddings, such as word representation, for biomedical named entity recognition (BioNER) has highlighted the need for evaluations that aid in selecting the best word embedding to be used. One common criterion for selecting a word embedding is the type of source from which it is generated; that is, general (e.g., Wikipedia, Common Crawl), or specific (e.g., biomedical literature). Using specific word embeddings for the BioNER task has been strongly recommended, considering that they have provided better coverage and semantic relationships among medical entities. To the best of our knowledge, most studies have focused on improving BioNER task performance by, on the one hand, combining several features extracted from the text (for instance, linguistic, morphological, character embedding, and word embedding itself) and, on the other, testing several state-of-the-art named entity recognition algorithms. The latter, however, do not pay great attention to the influence of the word embeddings, and do not facilitate observing their real impact on the BioNER task. For this reason, the present study evaluates three well-known NER algorithms (CRF, BiLSTM, BiLSTM-CRF) with respect to two corpora (DrugBank and MedLine) using two classic word embeddings, GloVe Common Crawl (of the general type) and Pyysalo PM + PMC (specific), as unique features. Furthermore, three contextualized word embeddings (ELMo, Pooled Flair, and Transformer) are compared in their general and specific versions. The aim is to determine whether general embeddings can perform better than specialized ones on the BioNER task. To this end, four experiments were designed. In the first, we set out to identify the combination of classic word embedding, NER algorithm, and corpus that results in the best performance. The second evaluated the effect of the size of the corpus on performance. The third assessed the semantic cohesiveness of the classic word embeddings and their correlation with respect to several gold standards; while the fourth evaluates the performance of general and specific contextualized word embeddings on the BioNER task. Results show that the classic general word embedding GloVe Common Crawl performed better in the DrugBank corpus, despite having less word coverage and a lower internal semantic relationship than the classic specific word embedding, Pyysalo PM + PMC; while in the contextualized word embeddings the best results are presented in the specific ones. We conclude, therefore, when using classic word embeddings as features on the BioNER task, the general ones could be considered a good option. On the other hand, when using contextualized word embeddings, the specific ones are the best option.

Dataset Information

Design, implementation, and operation of a rapid, robust named entity recognition web service.

Publications

Design, implementation, and operation of a rapid, robust named entity recognition web service.

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