Ontology highlight
ABSTRACT:
SUBMITTER: Frankell AM
PROVIDER: S-EPMC6420087 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Frankell Alexander M AM Jammula SriGanesh S Li Xiaodun X Contino Gianmarco G Killcoyne Sarah S Abbas Sujath S Perner Juliane J Bower Lawrence L Devonshire Ginny G Ococks Emma E Grehan Nicola N Mok James J O'Donovan Maria M MacRae Shona S Eldridge Matthew D MD Tavaré Simon S Fitzgerald Rebecca C RC
Nature genetics 20190204 3
Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving EAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. Using a cohort of 551 genomically characterized EACs with matched RNA sequencing data, we discovered 77 EAC driver genes and 21 noncoding driver elements. We identified a mean of 4.4 driver events per tumor, which were derived more commonly from mutations t ...[more]