Ontology highlight
ABSTRACT:
SUBMITTER: Kesharwani T
PROVIDER: S-EPMC6420224 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kesharwani Tanay T Kornman Cory C Tonnaer Amanda A Hayes Amanda A Kim Seoyoung S Dahal Nikesh N Romero Ralf R Royappa Andrew A
Tetrahedron 20180426 24
A convenient methodology for the synthesis of mono- and di-halogenated benzo[<i>b</i>]thiophenes is described herein, which utilizes copper(II) sulfate pentahydrate and various sodium halides in the presence of substituted 2-alkynylthioanisoles. The proposed method is facile, uses ethanol as a green solvent, and results in uniquely substituted benzo[<i>b</i>]thiophene structures with isolated yields up to 96%. The most useful component of this methodology is the selective introduction of bromine ...[more]