Bridging human chaperonopathies and microbial chaperonins.
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ABSTRACT:
SUBMITTER: Conway de Macario E
PROVIDER: S-EPMC6420498 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Bridging human chaperonopathies and microbial chaperonins.
Conway de Macario Everly E Yohda Masafumi M Macario Alberto J L AJL Robb Frank T FT
Communications biology 20190315
Chaperonins are molecular chaperones that play critical physiological roles, but they can be pathogenic. Malfunctional chaperonins cause chaperonopathies of great interest within various medical specialties. Although the clinical-genetic aspects of many chaperonopathies are known, the molecular mechanisms causing chaperonin failure and tissue lesions are poorly understood. Progress is necessary to improve treatment, and experimental models that mimic the human situation provide a promising solut ...[more]
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