Ontology highlight
ABSTRACT:
SUBMITTER: Sheng Z
PROVIDER: S-EPMC6420567 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sheng Ziyang Z Chen Hui H Feng Kaihao K Gao Na N Wang Ran R Wang Peigang P Fan Dongying D An Jing J
Virologica Sinica 20190221 1
Dengue fever, caused by dengue viruses (DENVs), is a widespread mosquito-borne zoonotic disease; however, there is no available anti-dengue vaccine for worldwide use. In the current study, a DNA vaccine candidate (pV-D4ME) expressing prM-E protein of DENV serotype 4 (DENV-4) was constructed, and its immunogenicity and protection were evaluated in immunocompetent BALB/c mice. The pV-D4ME candidate vaccine induced effective humoral and cellular immunity of mice against DENV-4 in vivo when administ ...[more]