Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
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ABSTRACT:
SUBMITTER: Garcia-Diaz A
PROVIDER: S-EPMC6420824 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Garcia-Diaz Angel A Shin Daniel Sanghoon DS Moreno Blanca Homet BH Saco Justin J Escuin-Ordinas Helena H Rodriguez Gabriel Abril GA Zaretsky Jesse M JM Sun Lu L Hugo Willy W Wang Xiaoyan X Parisi Giulia G Saus Cristina Puig CP Torrejon Davis Y DY Graeber Thomas G TG Comin-Anduix Begonya B Hu-Lieskovan Siwen S Damoiseaux Robert R Lo Roger S RS Ribas Antoni A
Cell reports 20170501 6
PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding t ...[more]
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