Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC7271235 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Fu Yujie Y Liu Connor J CJ Kobayashi Dale K DK Johanns Tanner M TM Bowman-Kirigin Jay A JA Schaettler Maximilian O MO Mao Diane D DD Bender Diane D Kelley Diane G DG Uppaluri Ravindra R Bi Wenya Linda WL Dunn Ian F IF Tao Yu Y Luo Jingqin J Kim Albert H AH Dunn Gavin P GP
Scientific reports 20200603 1
Encouraging clinical results using immune checkpoint therapies to target the PD-1 axis in a variety of cancer types have paved the way for new immune therapy trials in brain tumor patients. However, the molecular mechanisms that regulate expression of the PD-1 pathway ligands, PD-L1 and PD-L2, remain poorly understood. To address this, we explored the cell-intrinsic mechanisms of constitutive PD-L1 and PD-L2 expression in brain tumors. PD-L1 and PD-L2 expression was assessed by flow cytometry an ...[more]